Isoelectric Point (pI) Calculator

The isoelectric point (pI) is the pH at which a peptide has no net electrical charge. Enter any sequence to calculate pI, plot the pH-charge curve, and explore ionization at any pH.

Examples:
Bradykinin Oxytocin Angiotensin I Substance P Met-Enkephalin Glutathione Insulin A-chain LL-37
ℹ️ pKa values from Pace et al. (2009) Protein Science. N-terminus pKa = 8.0, C-terminus pKa = 3.1. Results may differ from experimental pI due to local structure effects.

What is the isoelectric point?

At its pI, a peptide carries no net electric charge and will not migrate in an electric field — a property exploited in isoelectric focusing (IEF) for protein separation. Below the pI the peptide is positively charged; above it, negatively charged.

pI < 7 — acidic peptide: dominated by Asp (D) and Glu (E) residues. Negatively charged at physiological pH. Examples: pepsin (~1.0), serum albumin (~4.7), insulin (~5.3).
pI ≈ 7 — near-neutral peptide: balanced mix of acidic and basic residues, or mostly non-ionisable residues. Minimal charge at physiological pH. Examples: hemoglobin (~6.8), myoglobin (~7.0).
pI > 7 — basic peptide: dominated by Arg (R), Lys (K), His (H). Positively charged at physiological pH — common among DNA-binding peptides, antimicrobial peptides, and cell-penetrating peptides. Examples: lysozyme (~11.0), histone H1 (~10.9), LL-37 (~11.1).

pI in Practice

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Isoelectric Focusing & 2D-PAGE

Isoelectric focusing (IEF) separates peptides within a pH gradient gel — each molecule migrates until it reaches its pI, where it stops. Combined with SDS-PAGE (2D-PAGE), it produces the high-resolution protein maps used in proteomics. The technique can resolve proteins differing by as little as 0.01 pH units in pI — enough to detect a single charge-altering amino acid substitution.

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Buffer & Formulation Design

Near its pI, a peptide has minimal charge repulsion between molecules, promoting aggregation. The practical rule: keep buffer pH at least 1–2 units away from the pI to maintain solubility. For example, insulin (pI ~5.3) is formulated at pH 7.4 in most injectables. Conversely, pI-based precipitation is deliberately used in purification — adjusting buffer pH to the pI selectively crashes a target protein out of solution.

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Notable pI Reference Values

A reference range of well-characterised proteins and peptides:

Pepsin~1.0
Serum albumin~4.7
Insulin~5.3
Hemoglobin~6.8
Cytochrome c~10.0
Lysozyme~11.0
Histone H1~10.9
LL-37 (cathelicidin)~11.1